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Lidocaine and verapamil are both used to treat cardiac arrhythmias and have bioavailability less than 40%, but lidocaine is never given orally because its metabolites are believed to contribute to central nervous system toxicity

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Side effects are similar to those of intracavernosal injection and include local pain (32%) and, in rare cases, persistent penile pain or priapism

Angiotensin II-dependent TGF-beta signaling contributes to LoeysDietz syndrome vascular pathogenesis

Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6

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